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 Post subject: Re: Medical news
PostPosted: 29 Mar 08, 15:57 
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How to find medical cover that won't give you a heart attack Independent


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 Post subject: Re: Medical news
PostPosted: 29 Mar 08, 16:19 
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Controversial push-button suicide machine to be rented to people with a death wish Mail


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 Post subject: Re: Medical news
PostPosted: 01 Apr 08, 16:03 
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Age-old tensions between wives and their mothers-in-law is reason for the menopause Mail


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 Post subject: Re: Medical news
PostPosted: 01 Apr 08, 16:08 
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Scots' prescriptions cut to £5 the same day English charges are RAISED to £7.10 Mail


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 Post subject: Re: Medical news
PostPosted: 01 Apr 08, 16:23 
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Tai Chi could help diabetics control blood sugar level

The Chinese Tai Chi martial art could help diabetics control their blood sugar, say experts.

They found its moderate exercise and deep breathing boosted the immune system in people with Type 2.

The team in Taiwan said it may cut blood glucose or improve how the body processes it.

Or it may improve fitness and the feeling of wellbeing, in turn boosting the immune system.

Diabetes UK said: "Any activity that leaves you warm and slightly breathless - vigorously cleaning the house, briskly walking the dog and Tai Chi - is moderate exercise."
Mirror


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 Post subject: Re: Medical news
PostPosted: 03 Apr 08, 16:06 
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Pregnant man bares his baby bump on TV for Oprah ultrasound scan Mail


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 Post subject: Re: Medical news
PostPosted: 03 Apr 08, 16:09 
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Two die and two more fight for life after learning organ donor had cancer Mail


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 Post subject: Re: Medical news
PostPosted: 08 Apr 08, 9:23 
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Are we being hoodwinked by alternative medicine? Two leading scientists examine the evidence Mail


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 Post subject: Re: Medical news
PostPosted: 09 Apr 08, 9:40 
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Scientists attack 'breakthrough' cancer drugs

Tried and tested? Or are some drugs rushed into clinics for desperate patients - and instant profit?


By Jeremy Laurance, Health Editor


Exaggerated claims are being made for new cancer treatments that are not justified by the evidence, scientists warned yesterday.

Drugs hailed as breakthrough treatments for cancer, Britain's biggest cause of death, may be less effective and cause more harm than suspected, they said.

A sharp increase in the number of trials being halted prematurely to deliver rapid results is undermining confidence in the drugs.

Public demand for access to new treatments, allied to the pharmaceutical companies' eagerness to bank profits, creates pressure on researchers to terminate trials as soon as a drug reveals a benefit. But that can be before the full results are in.

A review of 25 trials of cancer drugs that had been stopped early during the past decade because they had started to show a benefit to patients, found more than half (14) had been halted in the past three years. Of those, 11 were used to support an application for a drug licence in Europe or in the US, researchers discovered.

One of the research team, Giovanni Apolone, from the Mario Negri Institute for Pharmacological Research in Milan, said: "This suggests a commercial component in stopping trials prematurely. We are aware that trials stopped early because they are showing benefit may result in the identification of promising new treatments for patients.

"However, findings obtained in this way require subsequent confirmation. Without such evidence, unsafe and ineffective drugs could be marketed and patients' health could well be jeopardised."

The drugs tested in the trials that were stopped early include some of the biggest new discoveries in cancer therapy, touted as heralding a new golden age in treatment. They include Herceptin (trastuzumab) for breast cancer, Avastin (bevacizumab) for bowel and kidney cancer, Campto (irinotecan) for lung and bowel cancer, Sutent (sunitinib) for kidney and gastrointestinal cancer, Nexavar (sorafenib) for kidney cancer, and TaxolCarbo (carboplatin) for ovarian and lung cancer.

Dr Apolone said it could take years for the long-term benefits or dangerous side-effects of a drug to become evident, but the average duration of the 25 trials stopped early was just 30 months. Five had enrolled less than 40 per cent of the planned number of patients.

Only 4 per cent of the trials were halted because of serious adverse effects but Dr Apolone said the main worry was that early stopping exaggerated the beneficial effects.

Writing in the online edition of Annals of Oncology, the researchers say: "If a trial is evaluating long-term efficacy of a treatment of conditions such as cancer, short-term benefits – no matter how significant statistically – may not justify early stopping. Data on disease recurrence and progression, drug resistance, metastasis, or adverse events, all factors that weigh heavily in the benefit/risk balance, could easily be missed."

Stuart Pocock, professor of medical statistics at the London School of Hygiene and Tropical Medicine, who had no involvement in the study, said all trials should have independent monitoring committees of experts to advise on when they should be stopped early.

Statistically, stopping trials that showed early evidence of benefit while allowing the rest to run their full course would skew the overall results and exaggerate the benefits, he said.

"Overall, there is an underlying bias towards exaggeration [of the results]. We can pretty reliably claim there is exaggeration going on. This is not as sober an environment as it should be. It has an aura of hot-headedness about it."

Professor David Kerr, editor of Annals of Oncology, said researchers faced a dilemma. "If we see an effective cancer drug, it is our duty to get it into the clinic as quickly as possible. But we must not run down the quality of the evidence to support that drug."

Cancer drug trials stopped early

Herceptin

Breast cancer – two trials started 2001 and 2003

Avastin

Bowel cancer – trial started 2005

Campto

Lung cancer – trial started 1995

Sutent

Gastrointestinal cancer – trial started 2003

Nexavar

Kidney cancer – trial started 2003

TaxolCarbo

Ovarian cancer – trial started 1994

Independent


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 Post subject: Re: Medical news
PostPosted: 12 Apr 08, 15:48 
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Scientists claim videos are proof of Alzheimer's breakthrough






By Jeremy Laurance, Health Editor


An injection that dramatically relieved the symptoms of Alzheimer's disease within minutes would qualify as the discovery of the decade. That is exactly what was claimed yesterday for an experimental treatment being tested in America.

Scientists at the Institute for Neurological Research at the University of California have treated around 50 patients at a private clinic by injecting an anti-arthritic drug, etanercept, into the spinal column in the neck and then tilting the patients to encourage the drug to flow to the brain.

They claim 90 per cent respond to the treatment, usually within minutes, and have released videos of patients to prove it.

In one, a nurse sits down with an 82-year-old patient, Marvin Millar, who frowns and mumbles incoherently as she asks him identify everyday objects such as a bracelet and a pencil, which he is unable to do.

But five minutes after being injected with etanercept – according to the film which was supplied and edited by the clinic – he greets his wife. Visibly shocked, she says he has not recognised her for years. Mr Miller then hugs her.

In a separate interview, also supplied by the clinic, she describes his improvements four weeks later, saying he makes sense 90 per cent of the time now, compared with none of the time before treatment started.

After the BBC reported the claims yesterday, callers jammed the Alzheimer's Society's helpline demanding details of the treatment.

Experts urged caution, warning that the drug had been tried on only a very few patients and, crucially, had not been tested against a placebo in a randomised controlled trial.

Etanercept is not a new drug, but this is a novel use of it. The California researchers injected it between the cervical vertebrae at the back of the neck, just below the skull, directly into the spinal column. Tilting is thought to encourage the drug to cross the blood-brain barrier. In arthritis, the drug blocks a chemical – tumour necrosis factor-alpha (TNF) – which causes inflammation and pain in the joints. It is thought TNF may also influence inflammation in the brain, and that by damping down the process the drug may preserve brain function.

Professor Edward Tobinick, who is leading the research, said: "What we see is an improvement in ability to think and calculate, memory improves, verbal ability improves, [patients] find words easier, they seem happier and we often also see an improvement in gait in patients whose gait is affected."

The researchers said improvement usually continued with weekly injections until it reached a plateau at about three months. Some patients had been taking it for three years. But they have only published details of 15 patients in a pilot study.

An estimated 400,000 people suffer from Alzheim-er's disease in the UK and claims for new treatments are seized upon by relatives, desperate for any straw to clutch. Suzanne Sorenson, head of research at the Alzheimer's Society, said she had been sceptical of the claims when she heard about them in January but having seen the film foot-age, considered it was now time to run a trial.

"On the surface these results are exciting but we need to treat the study with caution," she said. "There are large gaps in the resear-ch, which used a small pilot group. We cannot draw conclusions until a controlled trial is carried out."

Clive Holmes, professor of biological psychiatry at Southampton University, a centre for research on dementia, said he was prepared to test the drug.

"The evidence from basic science suggests it is worth giving these drugs a trial to see if there is evidence on a larger basis," he said.

The elusive search for a cure

*A hundred years after Alzheimer's disease was discovered, a cure for the progressive neurodegenerative condition remains a distant dream. Despite dramatic breakthroughsin other areas, there has been little to celebrate in Alzheimer's. The main advance has been drugs to control symptoms such as agitation and restlessness. But restoring memory and cognitive ability has proved much harder.

The condition is caused by an accumulation of protein deposits in the brain which produce the symptoms of dementia.

There are three drugs with claims to halt the disease's progression (though not reverse it), Aricept, Reminyl and Exelon. In 2005 their NHS use was restricted to the moderate stage of the disease – as opposed to early or late stages – by the National Institute for Clinical Excellence because of their limited effect.
Independent


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 Post subject: Re: Medical news
PostPosted: 13 Apr 08, 14:24 
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GPs warned over failure to diagnose cancers


· Health chief's concern over mistakes
· Children and women most likely victims

Late diagnosis is seen as a major reason why the UK has poorer survival rates than some other countries in Europe. Photograph: Micro Discovery/Corbis

Patients are dying of cancer because GPs are failing to identify their symptoms, the government's top cancer expert has warned. Professor Mike Richards said botched diagnoses were now 'a significant concern'.

In an interview with The Observer, Richards, national cancer director at the Department of Health, warned about the consequences of these mistakes. 'Ultimately it can mean that the cancer has progressed to a stage where it can't be cured,' he said. Failed diagnoses also meant that, when cancers were eventually spotted, particularly aggressive treatments, such as chemotherapy or surgery, had to be used. 'That could be a mastectomy rather than perhaps a breast conserving operation,' he said.

The government's recent Cancer Reform Strategy identified late diagnosis as a major reason why the UK has poorer survival rates than some other countries in Europe. Although the cancer death rate is falling, it killed 153,491 Britons in 2005.

'There are 250,000 new patients with cancer every year,' said Richards. 'It's probably only a small proportion who experience a missed or delayed diagnosis. It's a small minority of patients overall. But it's not a negligible figure. We want to reduce this to the smallest possible number.'

Cancer in children and breast cancer were especially hard to diagnose, he said. 'There will be a significant number of women with breast cancer where this may happen, especially where cancer is uncommon, for example women under 50 and even under 40. This can happen among that group. It can happen with any cancer.'

There are no official annual statistics on the scale of the problem. But an unpublished joint study by the Health Department and the National Patient Safety Agency, which investigated records involving missed or late diagnoses of cancer patients from January 2004 to November 2006, showed:

· More than 1,900 patients - 55 a month - suffered a missed or late diagnosis, though officials admitted the problem was probably much greater;

· Patients waited for periods between a day and 23 months to have their condition confirmed because of diagnostic errors, often at their GP's surgery;

· Breast, bowel and lung cancer were the likeliest to involve a botched diagnoses;

· Blunders in hospitals added to delays in cancers being identified. These include X-rays, biopsies or blood tests misfiled or misread.

'This is an important issue because in some cases things are going wrong,' said Ben Thomas of the Patient Safety Agency. 'Nobody wants this to happen. Nobody wants to miss a diagnosis or have a late diagnosis. But it does happen. This could happen to anyone. Unfortunately people suffer and people die. We think that practitioner delay, where someone turns up at the GP with symptoms but there's a delay in the GP referring the patient to a specialist, is fairly common.'

Richards said some GPs felt they could not refer patients for tests as often as they would like in case hospitals became overloaded. 'Many patients are referred the first time they go to their GP. But some will go three, four, or even more times,' he said.

Richards's comments come as cancer charities warn that some GPs are wrongly telling sufferers they have other, less serious conditions, such as irritable bowel syndrome, haemorrhoids or gastroenteritis, and send them away with tablets. Similarly some patients in their twenties, thirties and forties are being misadvised by their GP that they are too young to have breast or bowel cancer, which mainly affects the over-50s, despite early signs of the disease.

Cancer experts agree it can be hard for GPs to identify correctly the signs of the disease, partly because the symptoms of certain cancers are also those associated with many other illnesses. A typical GP with a list of 1,800 patients will only see eight or nine new cancer patients every year, and there are about 200 different types of cancer.

'Cancer is difficult to identify and GPs sometimes get it wrong,' said Dr Steve Field, a Birmingham GP and the chairman of the Royal College of General Practitioners. Many of the signs of cancer, such as tiredness, weight loss and rectal bleeding, are also associated with many other conditions, making diagnosis difficult, Field said.

GPs sometimes did not glean enough information about a patient's health from their case history or physical examination to indicate if it is cancer, and some feel they need to see a patient several times before forming a judgment on what was wrong with them, he said.
Observer


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 Post subject: Re: Medical news
PostPosted: 14 Apr 08, 16:05 
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Two glasses of wine a day 'puts breast cancer risk up by 50 per cent'
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 Post subject: Re: Medical news
PostPosted: 14 Apr 08, 16:10 
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'Now we have the technology that can make a cloned child'

By Steve Connor, Science Editor
Independent


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 Post subject: Re: Medical news
PostPosted: 16 Apr 08, 9:39 
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A top obstetrician on why men should NEVER be at the birth of their child
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 Post subject: Re: Medical news
PostPosted: 16 Apr 08, 21:34 
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Vitamins A, C and E are 'a waste of time and may even shorten your life'
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